This post is also available in: TH (TH)

PLATELET-RICH
FIBRIN MATRIX

NEXT GENERATION PRP

A major advance in PRP science from the leaders in Fibrin matrix technology from the United states

Platelet-Rich Fibrin Matrix (PRFM) TECHNOLOGY was developed by “Cascade Medical” Enterprises, LLC from USA to address the shortfalls in current platelet rich plasma products and kits.
While it may appear that all PRP kits are essentially equal, there are important differences. The science and technology supporting the Selphyl®.

Mechanism

The Selphyl System is a completely closed system and can convert PRP to PRFM with the addition of a precise amount of calcium chloride dehydrate which initiates the conversion of fibrinogen to fibrin, as part of the clotting.

The fibrin matrix serves as a three dimensional scaffold to maintain the platelets at the site of injection. The scaffold also serves to protect the platelets so their release of growth factors can be sustained over a longer period of time.

Selphyl PRFM kits differ from all other PRP kits on these points

KEY CONSIDERATIONS

WHY IS IT
IMPORTANT?

SELPHYL PRFM

Minimize red cells in plasma

Reduces the risk of 
hemosiderin staining

yes

Minimize white cells in plasma

Reduces the risk of 
impairing tissue healing & 
remodeling

yes

Inject as a liquid that forms a fibrin matrix in situ

Reduces the risk of
hemosiderin staining

yes

Maintain a closed system and minimize user inferaction

Minimizes potential for 
contamination

yes

The main advantages & benefits
of Selphyl system

ADVANCE TECHNOLOGY

“Golden” Visual Guide to uality Ultrapure PRFM
  Remains in place; provides sustained effects
  Fibrin matrix scaffold: platelets are localized and viable (the release of growth factors over a period of 7 days)
  Converts PRP to PRFM Sustained growth factor release

SAFE SYSTEM

Control process system (minimize human error)
Completely Closed-System (minimizes potential for contamination)
Reduces the risk of impairing tissue healing & remodeling
Reduces the risk of iron accumulation under the skin

naturally yours THE POWER OF BLOOD

Whole
Blood

PRP
(w rbc/wbc)

PRFM
(minimize
rbc/wbc)

Blood performs
numerous functions
exquisitely

Other PRP Systems

Selphyl System

As part of the body’s capacity to heal itself, platelets and other components in human blood migrate to a site of injury. Platelets are known to release a variety of factors that respond to tissue injury, where they initiate and promote healing. By concentrating platelets at the site of injury, physicians have the potential to enhance the body’s natural capacity for healing.

The Selphyl® System provides the exact amount of Calcium Chloride to PRP producing Platelet-rich Fibrin Matrix. Other systems produce PRP, not PRFM. Fibrin matrix creates a scaffold to localize platelets to the site of injection and allows for sustained growth factor release, migration of stem cells and reservoir for regenerative signaling.

Whole
Blood

PRP
(w rbc/wbc)

PRFM
(minimize
rbc/wbc)

Blood performs
numerous functions
exquisitely

Other PRP Systems

Selphyl System

As part of the body’s capacity to heal itself, platelets and other components in human blood migrate to a site of injury. Platelets are known to release a variety of factors that respond to tissue injury, where they initiate and promote healing. By concentrating platelets at the site of injury, physicians have the potential to enhance the body’s natural capacity for healing.

The Selphyl® System provides the exact amount of Calcium Chloride to PRP producing Platelet-rich Fibrin Matrix. Other systems produce PRP, not PRFM. Fibrin matrix creates a scaffold to localize platelets to the site of injection and allows for sustained growth factor release, migration of stem cells and reservoir for regenerative signaling.
Main functions of the growth factors present
in platelet-rich plasma

PDGF

(Platelet Derived Growth factor)

Cell growth, new generation and repair of blood vessel collagen production

TGF-β

(Transforming Growth Factor Beta)

Growth and neogenesis of epithelial cell and vascular endothelial cell, promotion wound healing

EGF

(Epithelial Growth Factor)

Promotion of epithelial cell growth, angiogenesis, promotion of wound healing

FGF

(Fibroblast Growth Factor)

Tissue repair cell growth 

collagen production

VEGF

(Vascular Endothelial Growth Factor)

Promotion of angiogenesis

Promotion of wound healing

IGF

(Insulin Growth Factor)

Regulates Cell Growth

KGF

(Keratinocyte Growth Factor)

Growth of keratinocytes

PDGF

(Platelet Derived Growth factor)

Cell growth, new generation and repair of blood vessel collagen production

EGF

(Epithelial Growth Factor)

Promotion of epithelial cell growth, angiogenesis, promotion of wound healing

FGF

(Fibroblast Growth Factor)

Tissue repair cell growth 

collagen production

VEGF

(Vascular Endothelial Growth Factor)

Promotion of angiogenesis

Promotion of wound healing

IGF

(Insulin Growth Factor)

Regulates Cell Growth

KGF

(Keratinocyte Growth Factor)

Growth of keratinocytes

TGF-β

(Transforming Growth Factor Beta)

Growth and neogenesis of epithelial cell and vascular endothelial cell, promotion wound healing

application

Medical

Platelet-rich plasma (PRP) is a platelet concentrate that has widely been used to accelerate the healing of soft and hard tissues.

Growth factors work as stimulators of extrinsic cell migration, regulators of proteinases, collagen producers, and improve the strengthand quality of the repair, allowing shorter surgical and rehabilitation times with less invasive procedures.

PRP reduces pain and significantly increases function exceeding the effect of corticosteroid injection.
PRFM appears to be a safe and feasible treatment modality in patients with urologic disease. Further placebo-controlled trials are warranted.

Aesthetic

The platelets found in our blood do a host of beneficial things, such as stimulate the regrowth of collagen and elastin, the building blocks of young and healthy skin. When your own blood is injected back into your skin, the body naturally begins a healing process that helps rid of acne scars.
Selphyl PRFM addresses a root cause of skin aging by triggering the production of new cells and collagen. As soon as Selphyl PRFM is administered, growth factors are released into the layers of your skin.
Selphyl system allows for prolonged release of platelet growth factors in the scalp which stimulates stem cells, prolongs dermal papillae cell survival, and increases angiogenesis. These factors combine to prolong the Anlagen phase of hair growth and shorten the catagen (resting) phase. The result is increased hair thickness and hair follicle survival.
Selphyl can be injected to correct crepey skin, especially in areas near the lips, cheeks, and eyes—such as crows feet and under the eyes. Dermal fillers are injected to fill the voids that aging have caused, beginning at age 35—such as hollow cheeks, a gaunt mid-face line, lip augmentation, tear troughs, lower eyelid bags, temples, nasolabial folds, marionette lines, and in the hands for to reduce the appearance of thin skin.
Autologous fat grafting is more effective when using a platelet-rich fibrin matrix such as Selphyl – a discovery that could advance the ongoing development of fat grafting for plastic surgery.

application

Medical

Platelet-rich plasma (PRP) is a platelet concentrate that has widely been used to accelerate the healing of soft and hard tissues.

Growth factors work as stimulators of extrinsic cell migration, regulators of proteinases, collagen producers, and improve the strengthand quality of the repair, allowing shorter surgical and rehabilitation times with less invasive procedures.

PRP reduces pain and significantly increases function exceeding the effect of corticosteroid injection.
PRFM appears to be a safe and feasible treatment modality in patients with urologic disease. Further placebo-controlled trials are warranted.

Aesthetic

The platelets found in our blood do a host of beneficial things, such as stimulate the regrowth of collagen and elastin, the building blocks of young and healthy skin. When your own blood is injected back into your skin, the body naturally begins a healing process that helps rid of acne scars.
Selphyl PRFM addresses a root cause of skin aging by triggering the production of new cells and collagen. As soon as Selphyl PRFM is administered, growth factors are released into the layers of your skin.
Selphyl system allows for prolonged release of platelet growth factors in the scalp which stimulates stem cells, prolongs dermal papillae cell survival, and increases angiogenesis. These factors combine to prolong the Anlagen phase of hair growth and shorten the catagen (resting) phase. The result is increased hair thickness and hair follicle survival.
Selphyl can be injected to correct crepey skin, especially in areas near the lips, cheeks, and eyes—such as crows feet and under the eyes. Dermal fillers are injected to fill the voids that aging have caused, beginning at age 35—such as hollow cheeks, a gaunt mid-face line, lip augmentation, tear troughs, lower eyelid bags, temples, nasolabial folds, marionette lines, and in the hands for to reduce the appearance of thin skin.
Autologous fat grafting is more effective when using a platelet-rich fibrin matrix such as Selphyl – a discovery that could advance the ongoing development of fat grafting for plastic surgery.

Step by step proccess

Selphyl PRFM is a simple, safe, quick and minimally invasive outpatient procedure. Doctor can use a variety of pain management techniques prior to patient’s treatment to ensure his comfort throughout the process.

Step by step proccess

Selphyl PRFM is a simple, safe, quick and minimally invasive outpatient procedure. Doctor can use a variety of pain management techniques prior to patient’s treatment to ensure his comfort throughout the process.

01

After proper preparation of the skin, the patient’s blood will be drawn into a vacuum collection as the standard blood drawing procedure. The patient blood will be mixed with tri-sodium citrate solution which is the anticoagulation once combine with calcium in blood. Mix it well by rotating the tube 7 times.

02

The tube is then place into the centrifuge and spin with 2800 RPM for 6 minutes, at 2200 x g to separate the red and white cell blood from plasma and platelet suspension.

03

After the spin, the separate gel will be located in the middle to separate the blood cell from plasma and platelet. Rotate the tube 7 times to make platelets well-dispersed in plasma, and become platelet-rich plasma (PRP)

04

PRP is then transferred into a tube containing calcium chloride in close system.

05

The PRP that has transferred into the device will be rotated 7 times to combine with calcium chloride. In this process, the liquid transforms to Platelet rich fibrin matrix (PRFM) within 15 minutes.

06

The patient’s own PRFM is ready to use as deemed appropriate by the clinical use requirements.

02

The tube is then place into the centrifuge and spin with 2800 RPM for 6 minutes, at 2200 x g to separate the red and white cell blood from plasma and platelet suspension.

01

After proper preparation of the skin, the patient’s blood will be drawn into a vacuum collection as the standard blood drawing procedure. The patient blood will be mixed with tri-sodium citrate solution which is the anticoagulation once combine with calcium in blood. Mix it well by rotating the tube 7 times.

04

PRP is then transferred into a tube containing calcium chloride in close system.

03

After the spin, the separate gel will be located in the middle to separate the blood cell from plasma and platelet. Rotate the tube 7 times to make platelets well-dispersed in plasma, and become platelet-rich plasma (PRP)

06

The patient’s own PRFM is ready to use as deemed appropriate by the clinical use requirements.

05

The PRP that has transferred into the device will be rotated 7 times to combine with calcium chloride. In this process, the liquid transforms to Platelet rich fibrin matrix (PRFM) within 15 minutes.

The label approval by the Thai Food and Drug Administration, Health Canada, Department of Health & Human Services USA.

Quality system guarantee by BSI at United States of America: ISO 13485 Medical Devices Quality Management, by Royal Charter, CE Marking of Medical Devices

Quality management system – ISO 13485:2016 & EN ISO 13485:2016
EC Certificate – Production Quality Assurance

A major advance in PRP science  from the leaders in Fibrin matrix technology from the United states

Platelet-Rich Fibrin Matrix (PRFM) TECHNOLOGY was developed by “Cascade Medical” Enterprises, LLC from USA to address the shortfalls in current platelet rich plasma products and kits.
While it may appear that all PRP kits are essentially equal, there are important differences. The science and technology supporting the Selphyl®.

Mechanism

The Selphyl System is a completely closed system and can convert PRP to PRFM with the addition of a precise amount of calcium chloride dehydrate which initiates the conversion of fibrinogen to fibrin, as part of the clotting.
The fibrin matrix serves as a three dimensional scaffold to maintain the platelets at the site of injection. The scaffold also serves to protect the platelets so their release of growth factors can be sustained over a longer period of time.
Selphyl PRFM kits differ from all other PRP kits on these points

Key conside- rations

Why is
it
important?

SELPHYL PRFM

Minimize red cells in plasma

Reduces the risk of hemosiderin staining

yes      

Minimize white cells in plasma

Reduces the risk of impairing tissue healing &
remodeling

yes      

Inject as a liquid that forms a fibrin matrix in situ

Remains in place; provides
sustained effects

yes      

Maintain a closed system and minimize user inferaction

Minimizes potential for
contamination

yes      

The main advantages & benefits of Selphyl system

ADVANCE TECHNOLOGY

“Golden” Visual Guide to uality Ultrapure PRFM
  Remains in place; provides sustained effects
  Fibrin matrix scaffold: platelets are localized and viable (the release of growth factors over a period of 7 days)
  Converts PRP to PRFM Sustained growth factor release

SAFE SYSTEM

Control process system (minimize human error)
Completely Closed-System (minimizes potential for contamination)
Reduces the risk of impairing tissue healing & remodeling
Reduces the risk of iron accumulation under the skin
naturally yours THE POWER OF BLOOD

Blood performs
numerous functions
exquisitely

Other PRP Systems

Selphyl System

As part of the body’s capacity to heal itself, platelets and other components in human blood migrate to a site of injury. Platelets are known to release a variety of factors that respond to tissue injury, where they initiate and promote healing. By concentrating platelets at the site of injury, physicians have the potential to enhance the body’s natural capacity for healing.

The Selphyl® System provides the exact amount of Calcium Chloride to PRP producing Platelet-rich Fibrin Matrix. Other systems produce PRP, not PRFM. Fibrin matrix creates a scaffold to localize platelets to the site of injection and allows for sustained growth factor release, migration of stem cells and reservoir for regenerative signaling.

Main functions of the growth factors present in platelet-rich plasma

PDGF

(Platelet Derived Growth factor)

Cell growth, new generation
and repair of blood vessel
collagen production

EGF

(Epithelial Growth Factor)

Promotion of epithelial cell growth, angiogenesis, promotion
of wound healing

FGF

(Fibroblast Growth Factor)

Tissue repair cell growth 

collagen production

VEGF

(Vascular Endothelial Growth Factor)

Promotion of angiogenesis

Promotion of wound healing

IGF

(Insulin Growth Factor)

Regulates Cell Growth

KGF

(Keratinocyte Growth Factor)

Growth of keratinocytes

TGF-β

(Transforming Growth Factor Beta)

Growth and neogenesis of epithelial cell and vascular endothelial cell, promotion wound healing

application

Medical

Platelet-rich plasma (PRP) is a platelet concentrate that has widely been used to accelerate the healing of soft and hard tissues.
Growth factors work as stimulators of extrinsic cell migration, regulators of proteinases, collagen producers, and improve the strengthand quality of the repair, allowing shorter surgical and rehabilitation times with less invasive procedures.
PRP reduces pain and significantly increases function exceeding the effect of corticosteroid injection.
PRFM appears to be a safe and feasible treatment modality in patients with urologic disease. Further placebo-controlled trials are warranted.

Aesthetic

The platelets found in our blood do a host of beneficial things, such as stimulate the regrowth of collagen and elastin, the building blocks of young and healthy skin. When your own blood is injected back into your skin, the body naturally begins a healing process that helps rid of acne scars.
Selphyl PRFM addresses a root cause of skin aging by triggering the production of new cells and collagen. As soon as Selphyl PRFM is administered, growth factors are released into the layers of your skin.
Selphyl system allows for prolonged release of platelet growth factors in the scalp which stimulates stem cells, prolongs dermal papillae cell survival, and increases angiogenesis. These factors combine to prolong the Anlagen phase of hair growth and shorten the catagen (resting) phase. The result is increased hair thickness and hair follicle survival.
Selphyl can be injected to correct crepey skin, especially in areas near the lips, cheeks, and eyes—such as crows feet and under the eyes. Dermal fillers are injected to fill the voids that aging have caused, beginning at age 35—such as hollow cheeks, a gaunt mid-face line, lip augmentation, tear troughs, lower eyelid bags, temples, nasolabial folds, marionette lines, and in the hands for to reduce the appearance of thin skin.
Autologous fat grafting is more effective when using a platelet-rich fibrin matrix such as Selphyl – a discovery that could advance the ongoing development of fat grafting for plastic surgery.

Step by step proccess

Selphyl PRFM is a simple, safe, quick and minimally invasive outpatient procedure. Doctor can use a variety of pain management techniques prior to patient’s treatment to ensure his comfort throughout the process.

01

After proper preparation of the skin, the patient’s blood will be drawn into a vacuum collection as the standard blood drawing procedure. The patient blood will be mixed with tri-sodium citrate solution which is the anticoagulation once combine with calcium in blood. Mix it well by rotating the tube 7 times.

02

The tube is then place into the centrifuge and spin with 2800 RPM for 6 minutes, at 2200 x g to separate the red and white cell blood from plasma and platelet suspension.

03

After the spin, the separate gel will be located in the middle to separate the blood cell from plasma and platelet. Rotate the tube 7 times to make platelets well-dispersed in plasma, and become platelet-rich plasma (PRP)

04

PRP is then transferred into a tube containing calcium chloride in close system.

05

The PRP that has transferred into the device will be rotated 7 times to combine with calcium chloride. In this process, the liquid transforms to Platelet rich fibrin matrix (PRFM) within 15 minutes.

06

The patient’s own PRFM is ready to use as deemed appropriate by the clinical use requirements.

The label approval by the Thai Food and Drug
Administration
, Health Canada, Department of Health
& Human Services USA.
Quality system guarantee by BSI at United States of
America:
ISO 13485 Medical Devices Quality
Management, by Royal Charter, CE Marking of Medical
Devices
Quality management system – ISO 13485:2016 & EN
ISO 13485:2016
EC Certificate – Production Quality Assurance